Which of the following model organisms contributed the most to connecting the genetic strand and the biochemical strand of modern cell biology through the use of genetic techniques and biochemical techniques to show molecules interacting in vivo?A) Mutants of Drosophila melanogaster allowed for the mapping of genetic traits to particular chromosomes.
B) Yeast was used to isolate enzymes into a cell-free extract that could carry out fermentation.
C)Pea plants illustrated the behavior of trait inheritance between generations.
D) Yeast mutants and yeast two-hybrid systems allow for the characterization of genetic mutants and determination of how specific proteins interact within a living cell.

Yeast hybrid and two hybrid screening is a molecular technique which is used to discover and study the protein- protein interaction and protein DNA interaction by testing the physical interaction between two proteins or a single protein in a DNA molecule.

Yeast mutants such as Schizosaccharomyces pombe and sachromyces cerevisiae have valuable tools for the study of the eukaryotic cell, including DNA repair mechanism and cell cycle control.

Hence, the correct answer is option D