Fort Sumter, South Carolina is your answer
The opening shots of the American Civil War started after the Confederates open fired on Fort Sumter, which until that time was under Major Anderson. After hours of intense fighting, the Union expended all of their ammunition and had to surrender.
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[ Answer ]
Fort Sumter, South Carolina
[ Explanation ]
The war was started when some Confederates bombed soldiers standing guard at Fort Sumter. 34 Hours later, Union Forces surrendered.
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