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Leukoplakia is a white or gray patch that develops on the tongue, the inside of the cheek, or on the floor of the mouth. It is the mouth's reaction to chronic irritation of the mucous membranes of the mouth. Leukoplakia patches can also develop on the female genital area; however, the cause of this is unknown.

Leukoplakia. When you hold tobacco in one place in your mouth, your mouth becomes irritated by the tobacco juice. This causes a white, leathery-like patch to form, and this is called leukoplakia. These patches can be different in size, shape, and appearance.