Question

What is the difference between normal and sickle hemoglobin at the DNA, RNA, and protein (amino acid) level?

Answer 1

Sickle hemoglobin is a genetic disease caused by a point mutation in one base. Thus, DNA difference is in nucleotide sequence  Changed DNA sequence is then transcribed into RNA, which now contains GUG instead of GAG. This changed RNA sequence is translated into misformed protein containing valine instead of glutamine.

Answer 2

The difference between normal and sickle hemoglobin at the DNA, RNA, and protein is that a sickle hemoglobin at the DNA is a result of a point mutation from one base. The RNA in a sickle hemoglobin changes from GAG to GUG, and the protein (amino acid) level changes from GLU to Val). Sickle cell is a genetic disorder, which is produced by a change in the nucleotide progression that codes for a protein. In this example, sickle cell is produced by one single nucleotide being changed for another (so, instead of the DNA being AATTGC, it would be AATAGC).