The DNA (deoxyribonucleic acid) is made up of polynucleotides. In a DNA sequence, the nucleotides are joined together with the help of phosphodiester bonds.
The polymerization of the DNA is the process, in which these nucleotides come together and bind to each other with a phosphodiester linkage to form a long chain of DNA.
In case, the drug is inhibiting the polymerization, then it should inhibit the formation of phosphodiester linkage between nucleotides.
Hence, the antibiotic drugs that prevent bacteria growth by inhibiting DNA polymerization inhibit the formation of phosphodiester bonds.
