What is the difference between a hypothesis and a prediction? a hypothesis is a tentative idea or question that is waiting for evidence to support or refute it, while a prediction is a guess at the outcome of a hypothesis. a hypothesis is a tentative idea or question that is waiting for evidence to support or refute it, while a prediction is the result of a particular research. a hypothesis is a narrow idea or question that is waiting for evidence to support or refute it, while a prediction is the broad research topic that questions existing knowledge. a hypothesis is a tentative idea or question that is waiting for evidence to support or refute it, while a prediction is the evidence that either supports or refutes that idea. previous next?