Since 1000 is a much larger number, Median would be the best way to determine the center.
1, 2, 3, 4, 5, 6, 7, 8, 9, 1000
The Median would be 5 + 6 = 11 / 2 = 5.5
The spread would be the difference between the highest and lowest numbers: 1000 - 1 = 999