In order to factorize this, we will use the distributive property which means to multiply each of the terms in the next factor.
So, (2x2)+(2x4)+(-4x2)+(-4x4)
4+8-8-16=-12
As we can see, that the two 8s cancel each other leaving us with 4-16
Response B best resembles this relationship. If we use the distributive property here, we get (nxn)+4n-4n-16
Leaving us with, n^2-16
To check, we can substitute n for 2 and check if we get -12