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Both  civilizations relied on agriculture and were located along the fertile valleys of major rivers. In addition, both civilizations believed in numerous gods that governed the various spheres of their lives. They also developed an ancient system of writing with Mesopotamia taking a lead in developing cuneiform writing system. In contrast the civilizations were located in different regions with Egypt being situated along the Nile and Mesopotamia being located along the Euphrates and Tigris river.

The civilizations of Ancient Egypt and Mesopotamia were two of the earliest civilizations in world history. These two cultures shared many commonalities, but also had significant differences.

The civilization of Ancient Egypt developed along the Nile River. The proximity to the Nile allowed agriculture to flourish, and made it possible to sustain a large population. Similarly, Mesopotamia was the region between the Tigris and Euphrates rivers, and agriculture was made possible by this proximity to water. Another similarity was the fact that both civilizations had a polytheistic religion (they believed in the existence of many gods). Finally, both civilizations had similar social structures.

However, these civilizations also differed in many different ways. The religion of Mesopotamia was a pessimistic one. People in Mesopotamia believed that their gods were generally unkind, and that life involved a lot of suffering. Egyptians, on the other hand, had a more positive opinion of life and of the afterlife. Another difference was their treatment of women. In Mesopotamian culture, women had no power and were considered property. On the other hand, the Egyptians allowed women to own property, be independent and even become pharaohs.