Non-polar substances cannot dissolve in water. These substances are referred to as insoluble. In large organisms, it's important that some substances are insoluble to retrain structural or chemical features. For example, starch and glycogen are insoluble in water so that they can be effectively stored around tissues without affecting osmosis. Cellulose is insoluble in water because it is needed for structural support and high tensile strength to resist osmotic forces in plants. If it dissolves in water, it will lose these properties. Large plasma proteins in animals are also insoluble in blood plasma (mostly water) because they are needed to maintain oncotic pressure during the exchange of substances and formation of tissue fluid at capillary beds.