Which of the following is correct regarding initiation of Ivabradine in patients with heart failure?
a) Patients must be in sinus rhythm
b) All patients must be started on the lowest possible dose and then titrated up
c) Patients must be on a maximally tolerated dose of beta-blocker before starting Ivabradine
d) Ivabradine improves mortality in patients with heart failure
e) Patients must have a heart rate of at least 70 bpm before initiation
