Amino acid mutations in proteins can often dramatically alter the function of a protein; however, certain mutations can be conservative and preserve the function of a protein. Indicate how the following amino acid substitutions would likely impact the function of a protein.
a. In theory, substituting isoleucine with leucine_____yield a dramatic impact on the protein's function.
b. In theory, substituting lysine with glutamate____yield a dramatic impact on the protein's function.
c. In theory, substituting arginine with lysine____yield a dramatic impact on the protein's function.
d. In theory, substituting proline with histidine_____yield a dramatic impact on the protein's function.
