Which of the following changes to the amino acids of an enzyme would most likely result in a new reaction being catalyzed, and why would this likely happen?
a) Addition of a polar side chain, increasing substrate specificity
b) Deletion of an amino acid, altering the enzyme's shape
c) Substitution of a charged amino acid, changing the enzyme's active site
d) None of the above; enzymes are highly specific and rarely catalyze new reactions
