Nita's New Year's resolution includes reducing dieting and endurance exercise training. But in the Biochemistry course she takes, she starts to worry if her reduced B vitamin supply would allow her to last through all the training, especially at the beginning of the training, when she is still adjusting to different types of exercises. It turns out that she does need to be concerned about B vitamin insufficiency and the impact on training efficiency. Using pyruvate dehydrogenase complex, identify the potential connections between the B vitamin supply issues and pyruvate metabolism issues in glycolysis.