An insertion mutation of 13 bp has occurred in exon 5 of a gene that has 20 exons. The gene encodes for a protein with kinase activity. Of the following statements about the mutation and gene, which statement is most likely FALSE?

A. The mutation will change the reading frame in which the ribosome reads the mRNA coded by the gene.
B. The mutation was caused by a splicing defect.
C. If the mutant polypeptide still functions as a kinase, ATP will be used as a substrate.
D. There is a high likelihood that the mutant polypeptide will be shorter than the wild-type polypeptide.
E. The mutation will change the primary structure of the polypeptide encoded by the gene.