Wearable sensor technologies are essential to the realization of personalized medicine through continuously monitoring an individual's state of health Sampling human sweat, which is rich in physiological information, could enable non-invasive monitoring. Previously reported sweat-based biosensors either can only monitor a single analyte at a time or lack on-site signal processing circuitry Given the complexity of sweat secretion, simultaneous and multiplexed screening of target biomarkers es full system integration to ensure the accuracy of measurements
Figure 1 shows a flexible and fully integrated sensor array for multiplexed in situ perspiration analysis, which simultaneously and selectively measures sweat metabolites (such as glucose and lactate) and electrolytes (such as sodium and potassium ions), as well as the skin temperature. Fully integrated wearable sensor arrays bridge the (a) technological gap between signal transduction conditioning, processing and wireless transmission in wearable biosensors by merging plastic-based sensors el l ented circuit board that interface with the skin with (b) silicon integrated circuits consolidated on a flexible circuit board for complex signal processing. Fully integrated wearable sensor arrays (Figure 1) Figure 1 Images and schematic illustrations of the flexible integrated sensing array for multiplexed perspiration analysis (a) Photograph of a wearable exible enable a wide range of Integrated sensing array on a subt's wrist Integrating the multiplexed sweat personalized diagnostic and flattened flexible Integrated sensing argy. The red dashed box indicates the electrode patterns and the white dashed boxes indicate the locations of the physiological monitoring applications. febles sensor array and the wireless flexible printed circuit board b) Photograph of integrated circuit components (1) discuss the important design functions of packaging for integrated circuit (red dashed box figure 1a) (2) Discuss the technologies that might need to fabricate the working electrode patterns (red dashed box figure 1b) at nanoscale (3) Develop a process flow chart to fabricate the working electrode patterns
