What would be the predicted result of deleting RG1 from the Mediator?This would cause a loss of the Tail module and greatly decrease activated transcription.The Srb10/11 (cdk8/cyclin C) module would lack an attachment site, so the ability of Mediator to repress transcription would be greatly impaired.This would result in a headless mutant resulting in an elimination of Mediator binding to the CTD.There would be little consequence, since Gal 11 would still be present to provide a docking site for the Srb10/11 module.
