Which of the following is the primary mechanism to block polyspermy in humans and cattle.
Hyperpolarization of the plasma membrane also called the vitelline membrane.
Inactivation of sperm within the perivitelline space.
Modification to the zona pellucida that prevents further sperm penetration.
A mechanism within the cytoplasm of the oocyte that allows only 1 sperm to participate in syngamy.

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