how is acetylcholine (ach) removed from the synaptic cleft? view available hint(s)for part e how is acetylcholine (ach) removed from the synaptic cleft? acetylcholinesterase (ache; an enzyme) and endocytosis into the muscle fiber simple diffusion away from the synaptic cleft and endocytosis into the muscle fiber simple diffusion away from the synaptic cleft and acetylcholinesterase (ache; an enzyme) acetylcholinesterase (ache; an enzyme) only